Get Cellular Peptide Hormone Synthesis and Secretory Pathways: PDF

By Jens F. Rehfeld,Jens R. Bundgaard

the concept that of hormonal law utilizing intercellular peptide messengers dates again to the invention of secretin in 1902. the concept that used to be uncomplicated: A peptide is published from particular hormone generating cells, endocrine cells, into flow upon stimulation of the cells. The peptide hormone travels through blood to its aim, the cells of that are outfitted with particular receptors for high-affinity binding of the actual peptide hormone. Receptor binding in this case elicits motion of the objective cells. this idea has been heavily challenged via smooth biochemistry and telephone biology. therefore, it truly is now good demonstrated that the gene of a selected peptide hormone could be expressed in numerous forms of endocrine cells, in neurons, and in a few circumstances additionally in adipocytes, myocytes, osteoblasts, and immune cells. this day, just a couple of hormones – together with the outdated grasp hormone insulin – signify the unique endocrine paradigm. in its place, the frequent mobile synthesis now increases the qu- tion of ways the physique keeps the law of its services by way of peptide hormones whilst a hormone might originate from various cells.

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Cellular Peptide Hormone Synthesis and Secretory Pathways: 50 (Results and Problems in Cell Differentiation) by Jens F. Rehfeld,Jens R. Bundgaard

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