Read e-book online Sphingolipids: Basic Science and Drug Development (Handbook PDF

By Erich Gulbins,Irina Petrache

Sphingolipids are lipid elements of the plasma membrane in eukaryotic cells. they've got a big functionality in signaling mechanisms within the mobile. This ebook on sphingolipids presents insights into the fundamentals of sphingolipid biology and drug improvement, with a selected emphasis at the sphingolipid spinoff ceramide. within the first half easy services of sphingolipids are defined, in addition to the genetics of significant enzymes, sphingolipid metabolism and synthesis. the second one a part of this primary quantity makes a speciality of drug improvement and pharmacology. The e-book is meant for scientists in pharmacology, biochemistry and mobilephone biology with a spotlight on biomedical learn in addition to for clinicians operating in pharmacology, oncology, cardiology, neurology and infectious ailment.
Together with quantity 216 by means of an analogous editors, the gathering represents a different, finished paintings on sphingolipids, delivering details on either sphingolipids’ simple biology (including synthesis, metabolism and phone biology) and their very important functionality in a (patho-)physiological context.

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Get Programmed Cell Death in Cancer Progression and Therapy: 615 PDF

By Roya Khosravi-Far,Eileen White

Programmed phone loss of life (PCD) performs pivotal roles in tumor development, melanoma therapeutics and resistance of tumor cells to remedy. This publication examines the mechanisms fascinated with mediating and regulating PCD in melanoma. It additionally offers an in depth indication of the application of PCD in melanoma remedy. The ebook gains chapters at the present and way forward for RNA interference in therapeutics and Pathways enthusiastic about Stem telephone Survival and Death.

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Download e-book for iPad: Neurotransmitter Transporters: 175 (Handbook of Experimental by Harald Sitte,Michael Freissmuth

By Harald Sitte,Michael Freissmuth

This ebook is a consultant survey of the present prestige of the constitution, functionality, rules and molecular pharmacology of Neurotransmitter Transporters. It presents an outline of insights generated long ago 5 years. the quantity serves as an invaluable compendium of present suggestions and an inspiring place to begin. it's a resource for college students attracted to this rising box in addition to for knowledgeable scientists searching for an update.

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Download e-book for iPad: Molekularbiologie kurz und bündig (German Edition) by Horst Will

By Horst Will

Dieses Buch fasst den aktuellen Stand der Molekularbiologie kurz und knapp zusammen und gibt Auskunft über grundlegende Lebensprozesse. Die Themen reichen von der Struktur der DNA und ihrer Funktion in der Vererbung bis zur Entwicklung differenzierter Zellen von Organen und den Möglichkeiten, aus Gewebezellen wieder Stammzellen zu erhalten.

Aus dem Inhalt:
– Wie werden die Sequenzinformationen der DNA in Sequenzen von RNA und Proteinen übertragen?
– Wie wirken sich Variationen und Mutationen der DNA auf Zellfunktionen und Merkmale von Individuen aus?
– Wie wirken Enzyme und auf welche Weise vermitteln Proteine zelluläre Transporte, Bewegungen und Signale?
– Wie sind Zellen aufgebaut? Wie vermehren sie sich und wie entstehen aus Stammzellen differenzierte Zellen?
– Wie können ausgehend von Gewebezellen wieder Stammzellen erhalten werden?
– Wie altern Zellen und wie sterben sie?

Die Zielgruppen
Die komprimierte Darstellung des Inhalts in einem Bruchteil des Umfanges von Standardlehrbüchern der Molekularbiologie eignet sich besonders für Leser mit begrenzter Zeit. Dies gilt sowohl für Studierende und Quereinsteiger, die einen schnellen Zugang zu molekularbiologischen Themen suchen, als auch für Molekularbiologen im Berufsleben, die ihr Wissen auffrischen möchten.

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Download e-book for iPad: Asthma: Immunopathology and Immunotherapy / Immunopathologie by F. Kummer,Friedrich Kummer

By F. Kummer,Friedrich Kummer

Das Konzept des allergischen bronchial asthma hat lange Zeit so sehr dominiert, dass die Immunotherapie vielfach ohne gesicherte diagnostische Grundlage, halbherzig oder ohne die Feinheiten der Allergenvermeidung angewendet wurde. Die Forschung der letzten zehn Jahre hat uns eine derartige Ausweitung unseres Wissenshorizontes beschert, dass es an der Zeit schien, massgebliche Autoren zur gemeinsamen Diskussion der neuen Aspekte einzuladen. Das Buch berichtet von den neuesten Erkenntnissen uber zellulares Verhalten, unterschiedliche Zytokinmuster und autoimmunologische Aspekte bis hin zur modernen Allergenvermeidung, aber auch von der wirksamen medikamentosen Therapie der eosinophilen Entzundung the idea that of bronchial asthma being an "allergic sickness merely" has ruled above others to an volume, re-assessment of this factor within the mild of very fresh effects from learn in immunopathology appeared greater than past due. This quantity presents a present suggestion of thought and scientific perform of immunopathology and treatment of bronchial asthma, comprising broad and fresh laboratory information on atopy, intrinsic bronchial asthma, elements of autoimmunology, in addition to directions for allergen avoidance, immunotherapy and - final no longer least - pharmacological remedy of eosinophilic inflammati

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Download PDF by Sankar Ghosh: Handbook of Transcription Factor NF-kappaB

By Sankar Ghosh

contemporary proof proving the molecular hyperlink among unchecked, power irritation and melanoma has implicated the transcription issue NF-kB as a key think about either inhibiting apoptosis and selling cellphone proliferation. given that its preliminary identity two decades in the past as an easy regulating think about one small a part of the immune reaction, NF-kB is proving to be the main protean of all transcription components. it's been proven to operate in such a lot mobilephone forms as a key regulator of a couple of inducible genes. study at the duties and ensuing pathologies of NF-kB has been prolific, yet previously there was no consolidated, multidisciplinary reference.
offering contributions from top gurus concerned with seminal discoveries at the topic, Handbook of Transcription issue NF-kappaB is an access element to figuring out the extensive position of this largely studied issue. starting with a precis, the authors introduce the uninitiated reader to the complexities of the NF-kB procedure. They clarify how a mess of extracellular and intercellular signs built-in on the point of this transcription issue have resulted in primary insights approximately many points of gene law and sign transduction.
The chapters delve into particular study features in regards to the functionality and legislation of NF-kB in a couple of organic structures. They talk about irritation, innate and adaptive immunity, liver integrity, and frightened procedure improvement, in addition to the formation of hair, epidermis, enamel, and plenty of different points of the constructing vertebrate physique. The pathological results of extra NF-kB task are addressed in chapters on illnesses with regards to persistent irritation, equivalent to middle sickness, muscular dystrophy, melanoma, and tumor proliferation, in addition to ailments because of inherent deficiencies in NF-kB. The textual content culminates in a dialogue of present efforts to increase cures aimed toward inhibiting the aberrant job of NF-kB in several diseases.

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